TABLE 1.Comparison of intrinsic membrane properties between cells from control and SCI mice
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Control (n = 120) | SCI (n = 65) | |
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Resting membrane potential, mV | –63 ± 1 | –59 ± 1*** |
Resistance, MΩ | 513 ± 26 | 557 ± 44 |
Time constant, ms | 23 ± 4 | 22 ± 2 |
Capacitance, pF | 51 ± 3 | 47 ± 4 |
Steady-state outward current, pA | 1170 ± 69 | 1475 ± 93** |
Peak inward current, pA | –1584 ± 87 | –1673 ± 108 |
Rheobase, mV | 91 ± 6 | 86 ± 9 |
Spike height, mV | 53 ± 2 | 59 ± 2* |
Overshoot, mV | 16 ± 1 | 16 ± 1 |
Voltage threshold, mV | –45 ± 1 | –47 ± 1 |
For comparison of cellular properties, cells with membrane potentials more negative than –50 were considered. SCI, spinal
cord injury.
* P < 0.05,
** P < 0.01,
*** P < 0.0001.